![]() These patients highlight the importance of facial gestalt in the accurate identification of MWS when less common features are present.ĬHARGE syndrome Mowat-Wilson syndrome craniosynostosis intellectual disability minor malformations. This report increases the number of reported patients with MWS with unusual features, and is the first report of MWS in children previously thought to have CHARGE syndrome. Genotype-phenotype correlations were suggested in those with mild intellectual disability (two had a novel missense mutation in ZEB2, one with novel splice site mutation). Studies have shown that the CHD7 gene plays a crucial role in. Major Features of CHARGE Syndrome These are very common in CHARGE and relatively rare in other conditions. CHARGE is caused by a change (mutation) in a single gene called CHD7, located on chromosome 8. See the specific linked sections in the Management Manual for Parents for additional information about features. Sixteen patients have previously-unreported mutations in ZEB2. Signs & Symptoms Major Features of CHARGE Syndrome (very common in CHARGE and relatively rare in other conditions). Among the "unusual" patients, two patients had clinical features of charge syndrome including choanal atresia, coloboma, cardiac defects, genitourinary anomaly (1/2), and severe intellectual disability two patients had craniosynostosis and three patients had mild intellectual disability. CHARGE syndrome is a genetic disorder characterized by a specific and a recognizable pattern of anomalies, namely, Coloboma, Heart defects, Atresia of choana, Retardation of growth and/or development, Genitourinary defects, and Ear anomalies and/or deafness. In this report, we add 28 MWS patients with molecular confirmation of ZEB2 mutation, including seven with an uncommon presenting feature. These cases may be more difficult to diagnose. ![]() Then, thorough evaluation of the ears with auditory function, and choana (if possible), as well as other subtle clues (mild ventriculomegaly, thymus hypoplasia, arhinencephaly, etc.) should be performed. ![]() Less common clinical features include ocular anomalies, craniosynostosis, mild intellectual disability, and choanal atresia. CHARGE syndrome is a rare, autosomal dominant genetic disorder with an incidence of approximately 1 in 10,000 births. CHARGE is a mnemonic for coloboma, heart defects, choanal atresia, retarded growth and development, genital abnormalities, and ear anomalies. The three most telling symptoms are the 3 C’s: Coloboma, Choanal atresia, and abnormal semicircular Canals in the ears. Mowat-Wilson syndrome (MWS) is characterized by moderate to severe intellectual disability and distinctive facial features in association with variable structural congenital anomalies/clinical features including congenital heart disease, Hirschsprung disease, hypospadias, agenesis of the corpus callosum, short stature, epilepsy, and microcephaly. The diagnosis of CHARGE syndrome is based on the cluster of physical symptoms and attributes displayed by each child. unless advised otherwise by the doctor in charge of your care eat a low-fat, high-fibre diet, including wholegrains and at least 5 portions of fruit. ![]()
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![]() ![]() It is the perfect pick-me-up in between Disneyland visits. I know I will spend hours just relaxing and enjoying the magic of this little app – free from the AppStore. Ariel's Undersea Adventure offers fun for the littlest fans There’s also a menu button to press and see all of the location choices in list form, in case you want to look for a particular attraction or dining location. You can even enter the Animation Academy and learn how to draw one of the Fab 4 characters. I think my favorite games were trying to capture a photo of the Yeti from Matterhorn (I wish it saved these to my photos on my iPad!) and the epic pirate battle within Pirates of the Caribbean. Now I know I can keep him entertained with Ariel’s undersea friends, any time of the day. Quite a few of the interactive games are perfect for little ones and rated my 3 year-old’s seal of approval. (I won’t give away all the surprises, but there are a lot of them!) and back down to the Castle to explore all over again. You then end up back on Main Street, U.S.A. There’s even a section for Cars Land, opening soon – so I’m sure the app will be updated in the future with more interactive elements. Once you explore all of Disneyland, the landscape continues to the Disneyland Resort hotels, Downtown Disney District and then on to California Adventure. Pirates of the Caribbean gameĪs you scroll through the different lands, the music blends seamlessly from one area to the next and each new land offers lush backgrounds and foregrounds with all your familiar favorite scenes. Some attractions will feature a photo, others a short video of the ride in action, and still others will offer an interactive game or activity. From there you can just start touching various park icons to discover how you can explore. ![]() An image that makes any Disney fan just sigh with contentment. As you press the screen to enter the app, you are instantly transported to Sleeping Beauty Castle, with Walt standing in front. This is more like a way to be in Disneyland Resort virtually, with some extras thrown in too.Īs you would expect from an official Disney app – it is breathtakingly beautiful. That being said, I do want to put that little disclaimer in that for anyone looking for solid planning information, this is not the app for that. Maybe I take visiting Walt Disney World so often for granted, but even on my first visit to Disneyland last summer, I didn’t read one guide book or really do anything before I arrived. This may shock some, but I’m actually not a planner when it comes to Disney Parks. This is exactly how I like my Disney information and entertainment. When I heard the title, “Disneyland Explorer” I figured it would be more of a “fun” app vs. I instantly fell in love, and wanted to share my thoughts here with you all. Hey, I thought, I’ve been to Disneyland! And I have an iPad! I’d like to explore Disneyland ON my iPad! So I downloaded it. The past week has been a whirlwind of activity around the zannaland headquarters (aka my house) so I haven’t been keeping up with all the latest tweets and blog posts and news…However, I happened to see one of my favorite Disney cast members re-tweeting something about a new Disneyland Explorer iPad app. ![]() ![]() ![]() There is a tutorial here:, but if you can get it to work, you are a magician. I did have that kind of problem with Color, so I didn't paid attention to that, but for my documentary project, I had at least 5 times a file with the name MVI_0001.mov and Resolve mess it up. For Premiere Pro it's not a problem but when you try conform you XML file, Resolve looks for the clip and it doesn't necessary find the good one. ![]() One problem to watch out for is that you can't have two different clips with the same file name (on a different directory). You could start by exporting a AAF file from Premiere Pro but it seems that there is less special effect (dip to white for exemple) that is supported, and it takes so long to export as AAL and then I didn't find a way to import it correctly into Resolve 8. The XML file can then be read by Premiere Pro directly. It seems that Adobe is working on a fix for that.įor rendering and exporting back to Premiere Pro, you can use the preset "FCP7 XML roundtrip" on the render page and then I export the project in the conform tab in Resolve. So you need to open the sequence with Final Cut Pro, then reexport it as a XML FCP v5 file and then you can import it into Resolve. The problem then is that Resolve 8 needs a XML FCP version 5 file and currently Premiere Pro export it as a version 4. If you want to keep you effect like dip to white it's best to export your Premiere Pro sequence as a Final Cut Pro XML. It is a paid version that includes everything from the free version - plus the Neural Engine, which features multi-user collaboration and more.I've just finished a 45min documentary with Premiere Pro and Davinci Resolve. Of course, there are alternatives, but not as good as the DaVinci Resolve Studio. They are all compatible with Windows, Mac OS X, and Linux. Where can you run this program?Īll versions of the DaVinci Resolve software run on major platforms. It's no wonder DaVinci Resolve sets the standard for top-of-the-line media production. ![]() You can take advantage of built-in chat and timeline comparison tools to work with partners anywhere on the globe. This software version also includes a multitude of features such as speed warp retiming, facial recognition, and more. Working on a large collaborative group project? DaVinci Resolve Studio is a good choice. Support is provided for resolution projects at 4k and higher, plus automatic color matching/balancing, and frame rates of 120 frames per second. The audio workstation is a powerful inclusion, offering EQ and dynamics processing, full mixer, ADR tools, and countless plugins. Include audio during production with ResolveFX, FairlightFX plugins, and DaVinci Neural Engine. Cut Page is all about speed and efficiency, helping you to make quick edits in time to meet urgent deadlines. Highlights include features like ‘Cut Page' which allows you to work faster. Just like magicĮnjoy having complete control of editing and smooth navigation throughout your project with DaVinci Resolve. DaVinci Resolve is revolutionary digital editing software that offers cutting-edge features intended for artists and other professionals in the industry. Thanks to Black Magic Design, you can meet your deadlines and take your professional editing to the next level. ![]() ![]() ![]() To learn more about how and for what purposes Amazon uses personal information (such as Amazon Store order history), please visit our Privacy Notice. You can change your choices at any time by visiting Cookie Preferences, as described in the Cookie Notice. Click ‘Customise Cookies’ to decline these cookies, make more detailed choices, or learn more. Third parties use cookies for their purposes of displaying and measuring personalised ads, generating audience insights, and developing and improving products. This includes using first- and third-party cookies, which store or access standard device information such as a unique identifier. ![]() If you agree, we’ll also use cookies to complement your shopping experience across the Amazon stores as described in our Cookie Notice. We also use these cookies to understand how customers use our services (for example, by measuring site visits) so we can make improvements. Give it a little time – some cats take a bit longer than others to adjust and become familiar with the toy before playing.We use cookies and similar tools that are necessary to enable you to make purchases, to enhance your shopping experiences and to provide our services, as detailed in our Cookie Notice. You can also spray catnip onto the cat toy to help entice your cat! TRUETOUCH® TRUETOUCH® Give it a little time – some cats take a bit longer than others to adjust and become familiar with the toy before playing. ![]() My cat is not playing with Pop N Play - what can I do? Yes, press the button to the far left on the unit – this will turn the mouse chirping sound off. This is normal, too! Pop N Play™ will automatically reduce power to prevent damage and realign the toy with one of the port holes on the unit. It seems the Toy is getting stuck inside the dome sometimes. This is normal! Pop N Play™ features a 15-min auto-off function that automatically switches the unit off. Once the batteries are installed, the cover and screw must be reinstalled for the unit to operate properly. The battery cover can be removed using a small phillips head screwdriver. Quick 4 Press combined (purring + heartbeat) 8 hoursĬhina WOBBLE WAG GIGGLE™ BALL WOBBLE WAG GIGGLE™ BALLĬlick here for Pop N Play™ Instruction Manual Quick 3rd press combined (purring + heartbeat) 4 hours Huggie Kitty is not a chew toy and should be removed from pet if being used as one. Press and hold the heart button for 3 seconds to keep the sound module on for 8 hrs.Ĭlick here for HuggieKitty™ instruction manual Press the heart button once to keep the sound module on for 4 hrs. Yes, the sound module has a built-in auto shut-off. ![]() Press and hold the heart button for 5 seconds to turn off the sound module. Yes, you must press the heart button to turn on the sound module. Huggie is not a chew toy and should be removed from pet if being used as one.ĭo you turn the sound module on or off manually? The reusable, non-toxic, heat pack offers the comfort of physical warmth, while the simulated heartbeat insert. This special plush toy is designed to help reduce negative behaviors and become a loyal companion for your doggo. Remember to remove the heat pack and sound module. Give your pooch a soft puppy to snuggle with during times of stress with a Pet's Know Best HuggiePup Plush Dog Toy. Microwave for 45 seconds For results flip heat pack over after 20 seconds and continue heating. How many batteries are needed in the sound module?Ĭan I use rechargeable batteries in the sound module? Click here for HuggiePup™ instruction manual ![]() ![]() ![]() Minions have existed for at least 60 million years (If you're looking for more information about Minion reproduction, there's probably fan-fiction somewhere that can help you out, but you'll have to Google it on your own.) Though the supervillain Gru has a gun that can transform humans into Minions, it's only been seen in an amusement park ride, so most Minions presumably came from the sea. Minions sheds some light on their beginnings in an opening credits sequence that depicts them evolving in the ocean, similar to many other organisms, before emerging fully formed as they appear today (this is a departure from Darwin). The origin story of the Minions is dependent on two questions: 1) Where did the creatures themselves come from, and 2) where did the commercial phenomenon come from?įirst, let's tackle the little guys themselves. Minions emerge from the sea, ready to bring joy to the world. We also don't know what compels them to serve evil people, though Minions implies it's an evolutionary imperative, similar to the parasitism seen in the natural world (but only the cute kind, suitable for a McDonald's toy). Relatedly, the evolutionary function of some Minions having one eye while others have two eyes remains unclear. ![]() There are a few things we don't know about Minions that the new movie doesn't clarify: We don't know why they wear goggles, though they've done so for thousands of years (early goggles were fashioned from available flora). Kevin's the leader, Stuart's the musician, and Bob's the kid (he totes around a teddy bear that somehow makes him appear even more adorable - and, in an equally lovable detail, he's heterochromic). The new movie centers on three Minions - Kevin, Stuart, and Bob - who each become more distinct throughout the course of the film (or at least as distinct as gibberish-speaking henchmen can be). ![]() Though it's often tough for the layperson to distinguish one Minion from another, they all have unique personalities and names (which their masters quickly learn). They even have a few special abilities, like becoming glow sticks when they're snapped and shaken. Minions have been turned into evil purple versions of themselves, transformed into giants, crushed, tortured, and buried without being worse for wear (this may be the reason they've survived so long). They communicate using a gibberish language that's understandable to them and a few people who have longstanding relationships with them. They vary in height, but it's safe to say they're between 2 and 3 feet tall (though closer to 2). They're earnestly driven by the desire to serve an evil boss, though they often screw up because they're selfish, easily distracted, and generally inept. Minions are a species of tiny yellow henchmen they look like unusually dressed Mike and Ike candies. Of course, as with all great things in history, the existence of Minions prompts big questions: Where did these strange beings come from? Why do they inspire such polarizing reactions? And is there any deeper meaning to these unusual yellow creatures? 1) What are Minions? The quest takes them to a villain convention in Florida and, soon after, all around the world. Set in the late 1960s, the movie follows three Minions as they search for a new evil boss to rule their species. ![]() Minions is a spinoff and prequel to Despicable Me and Despicable Me 2, but instead of focusing on Steve Carell's Gru, it puts the spotlight on the Minions alone. But no matter what you think about the curious pill-shaped creatures, their fame is about to rise thanks to their starring role in the new movie Minions, now in theaters. Perhaps you've already decided whether you love them, hate them, or simply find them baffling, as they've been known to inspire quite a range of emotions in all who encounter them. You've probably heard of Minions, or maybe you've just seen their bright yellow likeness on a T-shirt, meme, or bumper sticker. ![]() ![]() ![]() Hey everyone! Have you ever dreamed of being a fox in a hyper-realistic world filled with prey and predators? Well, now you can with the Ultimate Fox Simulator 2 – the sequel to the most popular animal simulators of all time!Įxplore a massive world with our most realistic fox ever and take on the challenge of survival. ![]() Xem thêm Guess the Close Up Pics Quiz codes | Update 07/2023 Introduction about Ultimate Fox Simulator 2. Step 3: Add the correct gift code for the title Ultimate Fox Simulator 2. Step 2: Click to the area where you can input the code Ultimate Fox Simulator 2. Step 1: Access the website of Ultimate Fox Simulator 2. Share the steps to enter the coupon code for the game Ultimate Fox Simulator 2. The coupon code Ultimate Fox Simulator 2 is for events. The coupon code Ultimate Fox Simulator 2 is for newly-created accounts. Holding on for more complete news… The coupon code Ultimate Fox Simulator 2 has expired. Redeem the coupon to claim 50 Diamonds (Available).Įnter the coupon to receive 100 Gold (Valid).Įnter the gift code to receive 100 Tokens. PROMO CODESĪdd the code to receive 40 Coins (Valid).Įnter the code to receive 300 Coins (New).Īdd the coupon to receive 200 Coins (Valid). The game developer Gluten Free Games LLC is giving away plenty of special codes to Phanmem360 users to mark the release/update of the game Ultimate Fox Simulator 2. Get the latest gift code right away (Last updated on )! The latest promo code Ultimate Fox Simulator 2. So what are you waiting for? Get your hands on these precious items now and enjoy playing Ultimate Fox Simulator 2! ![]() Phanmem360 has already compiled the latest gift codes for Ultimate Fox Simulator 2, along with instructions on how to accurately apply them to receive complimentary prizes and a variety of valuable equipment while playing. Like many other titles out there, players can utilize free gift codes to race to the top and win easily. Ultimate Fox Simulator 2 has been well-received and popular among countless gamers, accumulating downloads and an impressive star rating from users. Hey there dear friends, are you feeling exhausted or disheartened and looking for some exciting pastime to kill time and relax? Well, you don’t have to look any further because Ultimate Fox Simulator 2 is here to save your day! This captivating game belongs to the genre of entertainment and is suitable for individuals of all ages. ![]() ![]() ![]()
![]() ![]() You might ask, isn't money a type of capital? Money is not capital as economists define capital because it is not a productive resource. You will notice that I did not include money as a factor of production. The payment to entrepreneurship is profit. Entrepreneurs thrive in economies where they have the freedom to start businesses and buy resources freely. Entrepreneurs are a vital engine of economic growth helping to build some of the largest firms in the world as well as some of the small businesses in your neighborhood. Think of the entrepreneurship of Henry Ford or Bill Gates. Without the entrepreneur combining land, labor, and capital in new ways, many of the innovations we see around us would not exist. The most successful entrepreneurs are innovators who find new ways to produce goods and services or who develop new goods and services to bring to market. An entrepreneur is a person who combines the other factors of production - land, labor, and capital - to earn a profit. The fourth factor of production is entrepreneurship. The income earned by owners of capital resources is interest. Your teacher may use textbooks, desks, and a whiteboard to produce education services. For example, a doctor may use a stethoscope and an examination room to provide medical services. Capital differs based on the worker and the type of work being done. Some common examples of capital include hammers, forklifts, conveyer belts, computers, and delivery vans. Think of capital as the machinery, tools and buildings humans use to produce goods and services. The third factor of production is capital. The income earned by labor resources is called wages and is the largest source of income for most people. If you have ever been paid for a job, you have contributed labor resources to the production of goods or services. ![]() It includes an artist's creation of a painting as well as the work of the pilot flying the airplane overhead. Labor resources include the work done by the waiter who brings your food at a local restaurant as well as the engineer who designed the bus that transports you to school. Labor is the effort that people contribute to the production of goods and services. The second factor of production is labor. The income that resource owners earn in return for land resources is called rent. These resources can be renewable, such as forests, or nonrenewable such as oil or natural gas. Land resources are the raw materials in the production process. Some common land or natural resources are water, oil, copper, natural gas, coal, and forests. ![]() This includes not just land, but anything that comes from the land. The first factor of production is land, but this includes any natural resource used to produce goods and services. Economists divide the factors of production into four categories: land, labor, capital, and entrepreneurship. The factors of production are resources that are the building blocks of the economy they are what people use to produce goods and services. ![]() ![]() ![]() ![]() "Drag Race star Gigi Goode slated after mocking Britney Spears with 'tone deaf' shaved head joke". "Why RuPaul's Drag Race's Gigi Goode Is More Than Just a Fashion Queen". "Drag Race's Gigi Goode Shares New ID With Updated Gender Marker". Filmography Television YearĮpisode "There's Something About Hamburger Mary's" ĭuring quarantine in 2020 she was living with the Los Angeles-based House of Avalon, which was described by Vogue 's Liam Hess as a "troupe of queer creatives", as of April 2020. She announced that she had started hormone replacement therapy in January 2021 and underwent facial feminization surgery. ![]() Initially identifying as genderfluid on RuPaul's Drag Race, Goode came out as transgender and non-binary on August 29, 2021, with a video on Instagram. At the 46th People's Choice Awards, she won an award in the "Competition Contestant of 2020" category. Goode and fellow Drag Race contestants Jaida Essence Hall and Shea Couleé appeared in the Savage X Fenty fashion show and Amazon Prime Video special Savage X Fenty Show Vol. In 2020, she and fellow Drag Race contestant Valentina appeared in the music video for " I'm Ready" by Sam Smith and Demi Lovato. Goode appeared in the music video for Chester Lockhart's 2018 cover of " I Put a Spell on You". Goode appeared in the Halloween-themed World of Wonder variety special Bring Back My Ghouls with other contestants from season 12 of Drag Race in October 2020. In mid-2020, she was one of a dozen former Drag Race contestants who was cast in the Drive 'N Drag concert series. Goode participated in Werq the World Battle Royale, a livestreamed fundraiser and drag show held during the COVID-19 pandemic. Critics praised Goode's performance on the show, highlighting her fashion and comedy skills. Jezebel called her portrayal of Maria "physical comedy gold" and "incredibly witty". During Snatch Game, she impersonated Maria the Robot, a character based on the experimental humanoid robot Sophia. Goode won the main challenges in episodes 4, 6, 7, and 12. Goode and her mother collaborated on many of the outfits Goode wore on the show. In 2020, Goode competed on the twelfth season of the reality competition series RuPaul's Drag Race, where she was the youngest contestant of the season and placed as a runner-up. She later dropped out of Millikin and moved to Los Angeles. Monroe Art Award in 2017, which honors "outstanding achievement in art, recognizing students for their major, excellence in their work and exhibiting a professional attitude". She attended Millikin University in Decatur, Illinois, where she majored in art and was awarded the David S. Goode attended Woodstock High School, where she graduated in 2016. She has said that her drag "became very 1950s and 1940s inspired". She started doing drag at an early age with the help of her mother, who initially disapproved of it, and she performed in drag in public for the first time at age 15. Goode was introduced to LGBT culture at the age of 12 by her openly gay uncle. Her mother, Kristi, is a costume and interior designer. Goode was born on December 2, 1997, in Woodstock, Illinois, and has Scottish and Scandinavian ancestry. Originally from Woodstock, Illinois, Goode attended Millikin University and, as of 2020, lives in Los Angeles. In 2020, she received a People's Choice Award in the Competition Contestant category. Following her appearance on Drag Race, Goode was cast in the Drive 'N Drag concert series, appeared in multiple music videos, and participated in a Savage X Fenty fashion show. Learn how to subscribe here.Gigi Goode (born December 2, 1997) is an American drag queen and reality television personality known for being a runner-up on the twelfth season of the drag competition series RuPaul's Drag Race. ![]() This story originally appeared in the March 2022 issue of Allure. She and some fellow Drag Race alumni - the villainously chic Tayce and A'Whora, the glamour clown Bimini Bon Boulash, and Goode's sister-in-charms, the reigning Drag Race champion, Symone - simply walked to and fro across stages in Manchester, Cardiff, Glasgow, and London, while packed crowds dutifully flipped their wigs in excitement. To that end, Goode's most recent project included a multistop tour across the United Kingdom in what she describes as a "traveling runway show." It's not really a performance so much as a series of outfits. ![]() ![]() While they are two different platforms, SOLIDWORKS and xDesign share many of the same functionalities, which is what makes it appealing to teachers using a SOLIDWORKS curriculum. To access the platform, all students need is a WiFi connection. None of these devices are powerful enough to run SOLIDWORKS.ĭuring distance learning, many engineering educators are turning to SOLIDWORKS xDesign, a browser-based CAD platform to teach their students CAD. However, the devices students most commonly have at home are Macs, Chromebooks, or tablets. These processors are often found in school computer labs. To access SOLIDWORKS, students need a high-powered machine. As access to SOLIDWORKS remains a concern during distance learning, educators look to web-based xDesign ![]() Since getting students access to SOLIDWORKS software during distance learning remains a challenge, Santana’s breakout session focused on how instructors can prepare their students for the Certified SOLIDWORKS Associate (CSWA) without ever downloading SOLIDWORKS. While there, he became a Certified SOLIDWORKS Instructor and a Certified SOLIDWORKS Professional (CSWP). Before founding SolidProfessor in 2002, Santana worked for a leading value-added reseller of SOLIDWORKS engineering and design software. One of the most-attended sessions was led by SolidProfessor president and co-founder, Pedro Santana. ![]() The summit included 19 sessions from industry experts and educators at Microsoft, Purdue University, SOLIDWORKS, Project Lead the Way (PLTW), and many more. This summer, SolidProfessor hosted a Virtual Education Summit for instructors, CTE directors, and administrators in engineering, architecture, and manufacturing education. ![]() |
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